Genetically inspired prognostic scoring system (GIPSS) outperforms dynamic international prognostic scoring system (DIPSS) in myelofibrosis patients
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چکیده
منابع مشابه
Dynamic International Prognostic Scoring System (DIPSS) predicts progression to acute myeloid leukemia in primary myelofibrosis.
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) with a high propensity to develop acute myeloid leukemia, named at this stage blast phase (BP) of PMF.1 Oncogenic JAK2 signaling is an important event in MPN, but transformation process into BP, although not completely understood, often involves additional genomic lesions.2 Several models have been developed to predict survival ...
متن کاملThe Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation.
Studies by the International Working Group showed that the prognosis of myelofibrosis patients is predicted by the Dynamic International Prognostic Scoring System (DIPSS) risk categorization, which includes patient age, constitutional symptoms, hemoglobin, leukocyte count, and circulating blasts. We evaluated the prognostic usefulness of the DIPSS in 170 patients with myelofibrosis, 12 to 78 ye...
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Among 200 patients with primary myelofibrosis, karyotype at diagnosis was abnormal in 83 (42%). To assess their individual prognostic impact, specific cytogenetic abnormalities with more than or equal to 5 informative cases were identified and the rest grouped separately as "other abnormalities." Median survival in patients with sole +9 (n = 6), sole 20q- (n = 21), sole 13q- (n = 8), normal kar...
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BACKGROUND In March 1997 an international workshop introduced a new International Prognostic Scoring System (IPSS) for MDS. The goal of the present study was to apply the IPSS to a large group of MDS patients from one centre and to compare it to the FAB-classification. PATIENTS One hundred eighty-four MDS patients were included on the basis of similar criteria as used by the workshop but some...
متن کاملMYELOID NEOPLASIA Revised International Prognostic Scoring System for Myelodysplastic Syndromes
Peter L. Greenberg,1 Heinz Tuechler,2 Julie Schanz,3 Guillermo Sanz,4 Guillermo Garcia-Manero,5 Francesc Solé,6 John M. Bennett,7 David Bowen,8 Pierre Fenaux,9 Francois Dreyfus,10 Hagop Kantarjian,5 Andrea Kuendgen,11 Alessandro Levis,12 Luca Malcovati,13 Mario Cazzola,13 Jaroslav Cermak,14 Christa Fonatsch,15 Michelle M. Le Beau,16 Marilyn L. Slovak,17 Otto Krieger,18 Michael Luebbert,19 Jaros...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2018
ISSN: 0361-8609
DOI: 10.1002/ajh.25335